The levels of CD151+, Tspan8+, and CD151+/Tspan8+ on the surface of CD9-positive exosomes in plasma of HFs were significantly lower than in OC patients (p < 0.05 for each case), wherein in both cases the Tspan8+ level was three times higher than the CD151+ level (p < 0.05). The gene discussed is TSPAN8; the disease is Hand-foot syndrome.