It is a cell surface glycophosphatidylinositol-linked protein belonging to the heparan sulfate proteoglycan family with highly negative charges, playing a crucial role in cell growth, differentiation, and migration by functioning as a coreceptor to modulate Wnt/beta catenin signaling in order to promote cell proliferation in HCC [87]. The gene discussed is CD44; the disease is hepatocellular carcinoma.