HCC-CAF-primed neutrophils suppress T cell activity by efficiently suppressing the T cell proliferation and IFN-γ production mainly through neutralization of PD-L1, which attenuated T cell suppression mediated by CAF-primed neutrophils, confirming that neutrophil mediates immune suppression through programmed death PD-1/PD-L1 pathway. The gene discussed is CD274; the disease is hepatocellular carcinoma.