Moreover, cancer-associated fibroblasts (CAFs) infiltrating HCC stimulate the activation and survival of TANs, shown by higher expression of CD66b, PD-L1, CXCL8, TNF-α, and chemokine ligand 2 (CCL2), where enrichment of CD66b+ neutrophils in the peritumoral region is associated with decreased overall survival of patients [29]. This evidence concerns the gene TNF and hepatocellular carcinoma.