Single cell gene expression database of tumor infiltrating Tregs (TIL-Tregs) exposed that these cells have higher expression of genes involved in Tregs proliferation and exhaustion, such as UHRF1, ID2, and CXCL13 [76], while CCR4-Tregs express granzymeH, LYN, CXCL9, and pro-melanin-concentrating hormone genes, which are involved in T cell differentiation and activation [77]. Here, CCR4 is linked to neoplasm.