TGFB1 and neoplasm: For instance, tumor-derived IL-10, TGF-β, and PGE2 can manifest DCs to attain regulatory rather than stimulatory functions, where IL-10 appeared most tolerogenic compared to other factors since it inhibited the maturation of these cells, restricted the expression of MHC class I and II and costimulatory molecules, and alleviated the production of inflammatory cytokines [46].