Among all TRP channels, TRPV6 is highly Ca2+ selective, with PCa/PNa values exceeding 100; such high Ca2+ selectivity is unique within the TRP superfamily (in addition to closely related TRPV5) and makes this channel quite distinguishable, especially in Ca2+-related intracellular pathways [2]. The gene discussed is TRPV6; the disease is posterior cortical atrophy.