Though the first team detected TRPV6 (previously called CAT1) in benign hyperplasia of the prostate (BHP) [4], the second claimed TRPV6 was not detectable in small sized and confined prostate tumors (grade T1), whereas TRPV6 transcripts were detected in 20% of tumors graded pT2a and pT2b, 79% of pT3a, and more than 90% of pT3b tumors which presented extra prostatic extensions [11] and thus TRPV6 transcripts are not detectable in the normal prostate, in benign, or in high grade prostate intraepithelia neoplasia [12,16]. Here, TRPV6 is linked to male reproductive organ cancer.