TNF and Hyperglycemia: Prolonged hyperglycemia in diabetes is associated with retinal microvasculopathy due to pericyte loss, acellular capillaries [2], capillary cell apoptosis, polyol-pathway-mediated basement membrane thickening [3], the release of vascular endothelial growth factor (VEGF) and proinflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β) [4], leukostatsis [5], and eventually, vascular hemodynamic changes, which are considered to play a pivotal role in diabetic retinopathy pathogenesis.