THY1 and neoplasm: Binding of TAM surface ligands Thy1 and EphA4 with EphA4 receptor of breast CSCs activated Src and NF-κB pathways [89], which in turn reinforced the secretion IL-6, IL-8 and granulocyte–macrophage-colony stimulating factor (GM-CSF), providing the self-renewal of tumor cells in vitro [90].