Interestingly, in glioblastoma cells, chrysin suppressed the expression of the Nrf2 protein and its major target genes as well as disrupting the ERK/Nrf2 signaling pathway without inducing kelch-like ECH-associated protein 1 (Keap-1) protein levels, the Nrf-2 negative modulator. Here, KEAP1 is linked to glioblastoma.