Finally, in accordance with the existent literature, Panther analyses applied on our data reveal, among others, angiogenesis, NOTCH, Toll receptor, WNT, and p53 signaling pathways as main pathways involved in PCa, suggesting that distinct, until now cryptic hypomethylation events underlie those well-established PCa associated pathway alterations (Figure 6). Here, TP53 is linked to posterior cortical atrophy.