Panther analyses [43,44] for the evolutionary and functional classification of protein-coding genes based on a library of over 15,000 phylogenetic trees, performed with all detected, gene-associated, and hypomethylated CpG probes, reveal their association with PCa-involved genes and pathways, e.g., angiogenesis, apoptosis, cell cycle, NOTCH and WNT signaling, and p53 pathway (Figure 6). Here, TP53 is linked to posterior cortical atrophy.