In an in vivo model of myocardial ischemia/reperfusion, 20 mg/Kg OLE increased SOD and reduced glutathione (GSH), while diminishing lipid peroxidation marker malondialdehyde (MDA) levels through a mechanism involving suppression of p-IκBα, p53, p-MEK, and p-ERK protein expression [81]. This evidence concerns the gene TP53 and myocardial ischemia.