Similarly, in a myocardial ischemia/reperfusion model, the reduction in serum IL-1β implied a decrease at protein level in phospho-IκBα (p-IκBα, an inhibitor of NF-κB), kinases phospho-MEK (p-MEK) and phospho-ERK (p-ERK), and cell survival/apoptosis ruling transcription factor p53 [81]. The gene discussed is TP53; the disease is myocardial ischemia.