Compared to normal tissues, significantly elevated mRNA expression levels of FAM72A were observed in 82% of 33 cancer types, including bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), GBM, lung squamous cell carcinoma (LUSC), lung adenocarcinoma (LUAD), and head and neck squamous cell carcinoma (HNSC) (Figure 1A,C). Here, FAM72A is linked to head and neck squamous cell carcinoma.