Interestingly, Gao et al. recently developed an angiogenesis factors-based prognostic signature in hepatocellular carcinoma, in which FAM72 is also one of six key genes (GRM8, SPC25, FSD1L, SLC386A, FAM72A, and SLC39A10) [14]. This evidence concerns the gene SPC25 and hepatocellular carcinoma.