JAK2 and neoplasm: However, it should be noted that the broad spectrum of UA in anticancer activity is to interfere with proteins related to tumor cell characteristics of proliferation, adhesion, migration, and survival through numerous signaling pathways, including hypoxia-, PI3K/AKT-, Wnt/β-catenin signaling [44,45,46], as well as JAK2/STAT3 transcription in changing pro-tumor microenvironments [47].