In this paper, we explore that UA interferes with CSC characteristics through inhibition of AGO2; Downregulation of AGO2-mediated biogenesis of CSC-related miRNAs, such as miR-9 and miR-221, by which the change in miRNA transcripts correlates with the reduction in slug and vimentin proteins during MET and prevents metastasis in MDA-MB-231 and MCF-7 breast cancer cell lines treated with UA. The gene discussed is AGO2; the disease is breast cancer.