These data support the underlying mechanism of UA that improves PTEN to decrease AGO2-mediated FAK/PI3K/Akt/mTOR signaling in conjunction with a reduction in c-Myc and pluripotent stem cell biomarkers, which is dedicated to the potential of UA as an effective natural phytochemical suppressor for breast cancer progression. The gene discussed is AKT1; the disease is breast carcinoma.