Serine protease, it is prominent among the histone-precipitated proteins. IαIP is composed to light and heavy chains (HC). In inflammation, IαIP interacts with TNF-stimulated gene six protein (TSG-6), which supports trans-esterification of HC to HA. In sepsis, IαIp inhibit granzymes and other proteases reducing their toxic proteolytic activity. Here, TNFAIP6 is linked to Sepsis.