In EOS increased with other molecules such as IL-6, TNF-α, HSP 70, PCT, and CRP.In VLBW with LOS the elevation of MMP-8 mRNA expression and activity in septic shock correlated with decreased survival and increased organ failure in pediatric patients and associated with TNF-α.MMP-8 is associated with poor prognosis in sepsis. This evidence concerns the gene IL6 and septic shock.