In the study of de Marañón AM [54], compared to the control (135 cases), leukocytes from patients with T2D (39 cases) exhibited lower expression of MFN1, MFN2 and OPA1 but higher expression of FIS1 and DRP1, and enhanced leukocyte adhesion to endothelial. Here, OPA1 is linked to type 2 diabetes mellitus.