PON2 and melanoma: Reported data clearly demonstrate that PON2 is overexpressed in different tumors, including, bladder cancer (BC) [19], ovarian cancer (OC) [20], pancreatic ductal adenocarcinoma (PDAC) [21], gastric cancer (GC) [22] and skin neoplasms, such as basal cell carcinoma (BCC) and melanoma [23].