Xu [19] examined NKG2D receptor levels and respective ligands (MICA, MICB, ULBP-2, and ULBP-3), finding a significant decrease in NKG2D in CD56+ NK cells in the peritoneal fluid of endometriosis subjects, decreased expression of ULBP-2 in the eutopic endometrium of endometriosis subjects, and decreased ULBP-3 expression in ectopic endometrial lesions. The gene discussed is KLRK1; the disease is endometriosis.