FN1 and acute respiratory distress syndrome: In ARDS, an imbalance between profibrotic and antifibrotic factors occurs due to the accumulation of macrophages, fibrocytes, fibroblasts and myofibroblasts in the alveoli, which favor the production of fibronectin, collagen and other components of the extracellular matrix, driving a mechanism of pathological fibroproliferation that results in lungs with fibrotic changes of varying degree, even in early stages of the disease [101].