Keywords applied were as follows: DNA polymerase theta, polymerase theta inhibitors, ART558, novobiocin, microhomology-mediated end joining, MMEJ, DNA repair, cancer, polymerase theta-mediated end joining, TMEJ, double strand break repair, homologous recombination repair, HR, non-homologous end joining, NHEJ, siRNA, shRNA, RNA interference, CRISPR/Cas9, anticancer therapy, and synthetic lethality. The gene discussed is POLQ; the disease is cancer.