The importance of platelets in the tumor microenvironment would therefore be intimately linked to the NAS/melatonin ratio, with consequences for intercellular fluxes and coordinated immune responses, including via NAS/TrkB/TGFβ in macrophages driving a tolerogenic dendritic cell phenotype that suppresses CD8+ t cells and NK cells. This evidence concerns the gene TGFB1 and neoplasm.