AhR activation is a significant regulator of the many functions of MSC, including suppressing the proliferation of bone marrow-derived MSCs, whilst enhancing mitochondrial function and mitochondrial transcription factor A (TFAM) [119], indicating the tumor-derived kynurenine, via AhR activation, will better optimize the mitochondrial function of MSC and attenuate MSC proliferation. This evidence concerns the gene TFAM and neoplasm.