CD274 and neoplasm: Platelets are involved in multiple processes in the tumor microenvironment, including angiogenesis [75], microvesicle release [76], and PD-L1 induction in cancer cells via NF-κB and/or TGFβ [77], with platelet-derived subtypes proposed to regulate metastasis [78], including via lncRNAs [79] and miRNAs [80].