CYP1B1 and neoplasm: As AhR activation lead to dramatic mobilization of MDSCs in the peritoneal cavity coupled to enhanced immune suppression, increased glycolysis, and mitochondrial respiration, coupled to alterations in miRNA patterning [100], it requires investigation as to the role of AhR-induced CYP1B1 and alterations in the regulation of the melatonergic pathway in MDSCs, including as to MDSCs melatonergic pathway regulation by tumor-released kynurenine and gut microbiome-derived AhR ligands, such as indole-3-propionate [101].