We know that the diaphragm muscle continuously supports cardiopulmonary function in a healthy individual by regulating inhalation, and exhalation processes; however, in DMD patients, the lack of dystrophin production leads to progressive diaphragm muscle (thoracic diaphragm) degeneration and necrosis along with respiratory muscles dysfunction (Figure 1). The gene discussed is DMD; the disease is Duchenne muscular dystrophy.