SLC12A3 and Hypokalemia: Ueda K. et al. [30] showed that ENaC and NCC, but not NKCC2, were activated in kidney-specific corticosteroid 11-β-dehydrogenase isozyme 2(Hsd11b2) knockout mice, suggesting that hypokalemia-induced NCC activation augments the renal-ENaC-activation-induced elevation of BP.