S100A7 and psoriasis: Human S100A7 induces IL-1α expression in keratinocytes through RAGE-p38 MAPK-calpain-1 signaling (Figure 1A,B), and psoriasis-associated cytokines, such as IL-17a, IL-22, and IL-36, may upregulate S100A7 expression in keratinocytes [159,160,161,162,163,164,165,166,167,168,169,170].