In vitro, the activation of NF-κB upon the interaction of S100A4 with RAGE has been reported in various cancer cells, including human osteosarcoma (II-11b), human melanoma (A375, B16-F10), and human pancreatic cancer (BxPC-3) cells [110,126,127,128,129]. This evidence concerns the gene AGER and familial pancreatic carcinoma.