In vitro data on the interaction of RAGE with S100B/P suggest a role in ovarian cancer, glioma (C6), and human colon adenocarcinoma by downregulating p53 and upregulating Akt1, STAT3, and in nasopharyngeal carcinoma, colon cancer, and pancreatic cancer by upregulating NF-κB, ERK1/2, MMP2, and MMP9 [256,298,299,313,314,315,316]. The gene discussed is STAT3; the disease is central nervous system cancer.