The expression of wild-type VDAC2 but not a mutant in which E73 was mutated to glutamine mediated SR-mitochondria Ca2+ transfer in cardiomyocytes, and the overexpression of wild-type VDAC2, but not E73Q, restored rhythmic cardiac contractions in a zebrafish arrhythmia model. This evidence concerns the gene VDAC2 and cardiac arrhythmia.