TLR8 and Cowden disease: However, very recently, Cerqueira et al. suggested that the TLR7/TLR8 region (and, in detail, Rs5979785 SNP) was associated with CD onset before 7 years of age in girls; however, the mechanistic significance of this finding is unclear, since a previous analysis did not identify any regulatory impact of Rs5979785 on the TLR7/TLR8 transcription.