TNF and viral infectious disease: The KEGG enrichment analysis showed that LPS activated the NLRs signaling pathway (mmu04621), NF-κB pathway (mmu04064), virus infection pathways (mmu05168, mmu05171, mmu05169, mmu05163, mmu167 et al.), TNF signaling pathway (mmu04668), PI3K-Akt signaling pathway (mmu04151), TLRs signaling pathway (mmu04620), JAK-STAT signaling pathway (mmu04630), and so on (Figure 5A, Table S12).