CASP3 and retinal degeneration: Our data are in agreement with a recent study reporting that the CB1R antagonist AM251 aggravated neurodegeneration in a rat model of light-induced retinal degeneration by increasing mRNA levels of pro-apoptotic markers (Bad, Bax) and activated cleaved caspase 3, as well as mRNA levels of the anti-apoptotic marker, Bcl-2.