Combined treatment with both AM1710 and SR141716 also diminished diabetes-induced reduction in NFL-IR intensity (AM1710 + SR141716: n = 8, 101.10 ± 13.08, #### p < 0.0001 compared to diabetic untreated, p > 0.05 compared to Control), but a statistically significant difference was not observed between the combined and single treatments (AM1710 + SR141716: p > 0.05 compared to AM1710 or SR141716 alone) (Figure 1B). Here, NEFL is linked to diabetes mellitus.