In addition, monocyte-derived DCs from patients with RA, when compared with healthy controls, secrete more pro-inflammatory chemokines (CXCL8 and CCL3) and cytokines (IL-6 and IL-23); skew the T-cell differentiation toward the Th17 lineage at the expense of regulatory T (Treg) cells; and attract more macrophages, neutrophils, and monocytes. The gene discussed is CXCL8; the disease is rheumatoid arthritis.