A proteomic study on BALF of CF, primary ciliary dyskinesia (PCD) and asthmatic patients identified that PCD and CF respiratory exosomes displayed higher levels of both grancalcin and histones [250], which mediate important properties of neutrophils such as their ability to adhere to fibronectin, their degranulation, and the increase in their killing antimicrobial activity [251]. Here, GCA is linked to primary ciliary dyskinesia.