EXOs collected from the CF patients’ airways were also characterized by high levels of superoxide dismutase (SOD2) and glutathione peroxidase 3 (GPX3), two proteins that can act synergistically in antioxidant defense, and peroxiredoxin 5 (PRDX5), all contributing to the regulation of airway inflammation. The gene discussed is SOD2; the disease is cystic fibrosis.