SST and temporal lobe epilepsy: Using an optogenetic approach, Shiri et al. showed that the selective LFLS of CaMKII neurons in the entorhinal cortices of juvenile mice in an in vitro 4-AP model of temporal lobe epilepsy, as well as the LFLS of PV or somatostatin interneurons, had an antiepileptic effect, which consisted of a reduction in ictal discharge frequency and duration [18].