Based on our findings, we can conclude that aPL induction after BNT162b2 vaccination occurs in a small number of individuals but not to the extent of infection and without clinical consequence, whereas SARS-CoV-2 infection induces aPL in a higher percentage of patients, with a small percentage of them having persistent aPL, but not to the extent seen in APS patients. This evidence concerns the gene FASLG and autoimmune polyendocrinopathy.