Importantly, multiple aPL positivity was observed much more frequently in APS patients (32.7% had triple-positive aPL) compared with COVID-19 patients (only 2.2% triple-positive aPL samples in the COVID-19 group II and 1.1% triple-positive aPL samples in the COVID-19 group III) and HCPs (no HCPs with triple-positive aPL). Here, FASLG is linked to autoimmune polyendocrinopathy.