Zhang et al. [28] were the first to report the presence of aPL in patients with COVID-19, and IgA was the most common isotype, which is also observed in our results (severely ill COVID-19 patients hospitalized in the ICU– group II), where patients had significantly elevated levels of anti-β2GPI IgA and aPS/PT IgA compared with HCPs. This evidence concerns the gene APOH and COVID-19.