In 2013, Lechner et al. confirmed the genotype-phenotype correlation, such that mutations of the missense type in the ZEB1 protein resulted in Fuchs’ endothelial dystrophy and keratoconus, while the nonsense or LoF mutations of ZEB1 produced a Stop codon, truncating the protein, causing PPCD3 [14]. This evidence concerns the gene ZEB1 and keratoconus.