Mei et al. reported that a series of Ru(II) complexes containing phenanthroimidazole derivatives with different structural modifications, such as (Ru[phen]2[p-tFMPIP])(ClO4)2, can interact with c-myc G-quadruplex DNA and induce the DNA-damage-mediated apoptosis of tumor cells [19]. Here, MYC is linked to neoplasm.