MYC and liver cancer: Liu et al. found that a class of dinuclear Ru(II) complexes, especially ([phen]2Ru[bpibp]Ru[phen]2)(ClO4)4, can selectively bind to the c-myc G-quadruplex DNA to decrease the expression of the c-myc gene, resulting in liver cancer HepG2 cell apoptosis [18].