miR-142-3p functions as a tumor suppressing miRNA by decreasing the expression of tumor-promoting genes such as high-mobility group box 1 (HMGB1), phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), Nuclear Receptor Subfamily 2 Group F Member 6 (NR2F6), and X-linked inhibitor of apoptosis protein gene (XIAP) [44,45,46,47]. This evidence concerns the gene PIK3CA and neoplasm.