The hypoxic environment in melanoma is responsible for the initiation of metastasis through the induction of major metastatic cascades, the suppressive role of miR-205, melanoma cell proliferation (miR-205, E2F1, miR-211), increased migration and invasion of melanoma cells (miR-1290, miR-211), phenotypic plasticity, drug resistance and increased cellular heterogeneity [97,98,99,100]. Here, E2F1 is linked to melanoma.