Future studies should address whether the FSGS plasma-induced perilipin-2 expression associated with lipid droplet accumulation in podocytes that we describe here is merely a biomarker for the presence of CPF(s) in plasma, is directly involved in the pathogenesis of podocyte injury or, conversely, is a protective response of the podocyte to safeguard itself from further injury and death. The gene discussed is NR5A2; the disease is focal segmental glomerulosclerosis.