On the other hand, the study of the transcriptome of Crtap and oim osteocytes from femora and tibiae has shown similar alterations in both OI murine models, including type I collagen coding genes (Col1a1 and Col1a2), bone-related transcripts Bglap and Bglap2 (OST) and Sparc (osteonectin), and alterations in Wnt and TGF-β signaling pathways, suggesting a cellular attempt to increase osteoblast differentiation and function in response to pathogenic ECM [23]. This evidence concerns the gene SPARC and osteogenesis imperfecta.