In the context of ccRCC, upregulated WNK1 stimulates the phosphatidylinositol 4-kinase IIIα (PI4KIIIα) enzyme, which controls the phosphatidylinositol-4,5-diphosphate-dependent PLC-β signaling leading to DAG-mediated activation of TRPC6. This evidence concerns the gene TRPC6 and nonpapillary renal cell carcinoma.