SETD5 and Epileptic encephalopathy: The significant reduction in total setd5 mRNA observed in the brain of heterozygous mutants compared to sedt5+/+ brain samples suggests that the mutant setd5 transcripts may be subjected to nonsense-mediated decay, as previously demonstrated in a de novo setd5 mutation isolated in a patient with early-onset epileptic encephalopathy [30].