At the early stage of PC among patients, the age group of under 55 years old expressed ligands (DLL1, DLL3, JAG1), Notch-specific TFs (HES1 and HEY1), and major components of the γ-secretase complex (PSEN1, PSEN2, PSENEN, NCSTN). The gene discussed is HES1; the disease is pachyonychia congenita.