In turn, the profiles of the components of the intermediate filaments, such as FLG (filaggrin) and VIM (vimentin), distinguished the group of 60–70-year-olds from all groups at the early stage of the disease, with lowered FLG expression and heightened VIM expression therein; whereas, with PC progression, elevated FLG expression was kept only among patients above 70 years old, and significantly, this group acquired VIM expression while the others maintained the early stage profile. This evidence concerns the gene FLG and pachyonychia congenita.