Furthermore, some of the Notch genes differentiated DFS with tumor stage within patients aged 60–70 years old, such as ADAM10, DTX3L, DVL3, and HDAC1, which were significantly lowered at the early stage (ADAM10: HR = 14.4, p = 0.0043; DTX3L: HR = 11.2, p = 0.016; DVL3: HR = 9.73, p = 0.023; HDAC1: HR = 9.4, p = 0.025) and heightened at the late stage (ADAM10: HR = 0.373, p = 0.011; DTX3L: HR = 0.515, p = 0.034; DVL3: HR = 0.299, p = 0.0019; HDAC1: HR = 0.398, p = 0.037) of PC. This evidence concerns the gene HDAC1 and pachyonychia congenita.