In the group of PC patients aged 60–70 years old at the early stage of the disease, 58 patients (69%) had a common Notch profile of NOTCH3, APH1A, HDAC2, MFNG, and DTX4, improving the DFS prognosis (HR < 0.001, p = 0.021, Figure 2), while 124 (73.4%) patients at the late stage of PC showed the profile of HES5, ADAM17, CREBBP, DVL3, and ADAM10 (HR = 0.35, p = 0.0016, Figure 2). The gene discussed is HES5; the disease is pachyonychia congenita.