Significantly, 13 genes overlapped between groups of patients below 55 and 60–70 years old (early vs. late tumor stage DOWN-UP: KAT2B, NUMB, DVL2, MAML1, PTCRA, CREBBP, MAML2, NOTCH2, APH1B, ADAM17, RBPJL, UP-DOWN: SNW1, LFNG), while none of the genes intersected between these groups and the elderly men. The gene discussed is APH1B; the disease is neoplasm.