Furthermore, some of the Notch genes differentiated DFS with tumor stage within patients aged 60–70 years old, such as ADAM10, DTX3L, DVL3, and HDAC1, which were significantly lowered at the early stage (ADAM10: HR = 14.4, p = 0.0043; DTX3L: HR = 11.2, p = 0.016; DVL3: HR = 9.73, p = 0.023; HDAC1: HR = 9.4, p = 0.025) and heightened at the late stage (ADAM10: HR = 0.373, p = 0.011; DTX3L: HR = 0.515, p = 0.034; DVL3: HR = 0.299, p = 0.0019; HDAC1: HR = 0.398, p = 0.037) of PC. The gene discussed is ADAM10; the disease is pachyonychia congenita.