At the late stage of PC in patients below 55 years of age, similarly to early and then late PC in 60–70-year-olds, we observed heightening of Notch activity through triggering the expression of additional ligands (DLL4, JAG2, DLK1), Notch receptors, TFs (HES4, HES5, HEY2, HEYL, PTCRA), and intensified cross-talk with the Wnt pathway through DVLs (DVL1, DVL2) until its activity extinction in elderly men, especially at the late stage of PC. This evidence concerns the gene DVL1 and pachyonychia congenita.