VIM and pachyonychia congenita: In turn, the profiles of the components of the intermediate filaments, such as FLG (filaggrin) and VIM (vimentin), distinguished the group of 60–70-year-olds from all groups at the early stage of the disease, with lowered FLG expression and heightened VIM expression therein; whereas, with PC progression, elevated FLG expression was kept only among patients above 70 years old, and significantly, this group acquired VIM expression while the others maintained the early stage profile.