IDH1 and central nervous system cancer: Most of the other changes for older/newer classification of the gliomas repeated those observed for the gene expression clustering, with the exception that both “astrocytomas, IDH-mutant” and «oligodendrogliomas, IDH-mutant, and 1p/19q-codeleted» formed not one, but two clusters (mC4/mC7 and mC5/mC6, respectively) and that grade 4 “astrocytomas, IDH-mutant” were not clustered together with “glioblastomas, IDH-wildtype” (Figure 5).