SMAD4 and colon adenocarcinoma: One mutation affected the MAP3K1 gene (p.N1125D), which was described in the COSMIC database in one breast cancer tumor sample, one mutation was located in the ERBB2 gene (p.V842I), which has been observed to be substantially more frequent in colon and endometrial cancers, and an additional one was found in the SMAD4 gene (p.R361H), which is also remarkably frequent in colon adenocarcinoma and pancreatic cancer (Table S6).