Sirt5 has also been shown to improve renal function in cisplatin-induced AKI by regulation of nuclear factor-erythroid factor 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) and B-cell lymphoma 2 (Bcl-2) in human kidney HK-2 cells [94]. Here, HMOX1 is linked to acute kidney injury.