Another study demonstrated that while FTI efficacy was limited due to alternative prenylation of K-Ras and N-Ras, combination treatment of either FTI or GGTI-1 with lovastatin synergistically induced apoptosis and inhibited MM cell proliferation, migration, K- and N-Ras processing and RAS-to-MAPK signaling [76]. This evidence concerns the gene KRAS and Miyoshi myopathy.