PRKG1 and myocardial infarction: In addition, genome-wide association studies (GWAS) have associated variants in VEGFA with coronary heart disease [32] and myocardial infarction [24], and variants in other gene targets of miR-20a-5p, CDKN1A (also a common gene target of miR-181a-5p) [23] and PRKG1 [33] with stroke.