We investigated the possible association between BB-DNA and plasma BDNF levels in AD and MCI patients using multivariate linear regression that included the main independent variables that may affect BDNF production (i.e., age, sex, AChEI, benzodiazepines, antidepressants, lipid-lowering medications, plasma BDNF levels, alcohol consumption, smoking habits, and PASE score) [22] (Table 2). This evidence concerns the gene BDNF and Alzheimer disease.