HDAC4 and amyotrophic lateral sclerosis: We demonstrated that the deletion of HDAC4 in the skeletal muscle worsens muscle function in SOD1 HDAC4mKO female mice even before the ALS onset, as in male mice [19], and exacerbates the ALS pathological features at a late stage of the disease, confirming the protective role of HDAC4 in skeletal muscle in ALS.