Additionally, Kaminskyy et al. targeted EPHA2 expression with specific siRNA in NSCLC cell lines, and highlighted the amplification of apoptotic signaling after an EPHA2 knockdown combination with ionizing radiation due to the partial phosphorylation reduction of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) [64]. The gene discussed is EPHA2; the disease is non-small cell lung carcinoma.