Recently, both Kou et al. and Anderton et al. extensively reviewed the implication of diverse EPHs/ephrins in LC and outlined the tumor-promoting effects of EPHA1, EPHA2, EPHA4, EPHA5, EPHA7, EPHB3, EPHB4, ephrin-A3, and ephrin-B2, as well as the tumor-suppressive effects of EPHA3, EPHB6, and ephrin-B3 [35,36]. Here, EPHB4 is linked to neoplasm.