Additionally, Kaminskyy et al. targeted EPHA2 expression with specific siRNA in NSCLC cell lines, and highlighted the amplification of apoptotic signaling after an EPHA2 knockdown combination with ionizing radiation due to the partial phosphorylation reduction of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) [64]. This evidence concerns the gene PRKDC and non-small cell lung carcinoma.