We have recently reported the preventive and protective effects of δT3 and αTF supplementation on markers of hepatic steatosis (FLI and L/S ratio), insulin resistance (HOMA-IR), oxidative stress (MDA), inflammation (hs-CRP, TNF-α, IL-6, leptin and adiponectin) and hepatocyte apoptosis (CK18-M30) in patients with NAFLD [11]. The gene discussed is LEP; the disease is metabolic dysfunction-associated steatotic liver disease.