In the current work, we aimed to explore changes in selected liver-related circulating miRNAs expression profiles in response to δT3 and αTF supplementation plus lifestyle modifications and correlate these changes with markers of hepatic steatosis (FLI and L/S ratio), insulin resistance (HOMA-IR), oxidative stress (MDA), inflammation (hs-CRP, TNF-α, IL-6, leptin and adiponectin) and apoptosis (CK18-M30) in patients with NAFLD. The gene discussed is LEP; the disease is metabolic dysfunction-associated steatotic liver disease.