To further clarify the role of p-ERK1/2 in plectin regulation of HCC cell migration, we treated shNC and shPLEC cells with tBHQ, and found that tBHQ treatment did not change the expression of total ERK1/2 (t-ERK1/2) but restored the expression of p-ERK1/2 in MHCC97H and MHCC97L cells. This evidence concerns the gene PLEC and hepatocellular carcinoma.