This study, together with the results of Lloyd et al. [26] showing subtle myofiber-type specific differences in muscle function for the 10-month-old BLAJ soleus and EDL muscles (that were not fully accounted for by altered myofiber-type composition), implicates dysferlin deficiency in the disruption of EC coupling, potentially contributing to impaired muscle function in dysferlinopathy. The gene discussed is DYSF; the disease is neuromuscular disease caused by qualitative or quantitative defects of dysferlin.