The ABCB5+ MSCs injected into the wound edges of excisional wounds in an iron-overload mouse wound model mimicking nonhealing human venous ulcers [94] markedly improved tissue remodeling with increased maturation and improved organization of collagen fibers similar to acute wounds, which was associated with reduced scar formation and improved tensile strength of the scar tissue [11]. The gene discussed is ABCB5; the disease is varicose ulcer.