Human skin-derived ABCB5+ MSCs, manufactured as a homogenous, standardized, highly pure ATMP with proven potency, bear potential to make a significant contribution toward fulfilling unmet needs of patients suffering from various inflammatory, immunological and/or degenerative diseases for which current treatments are lacking or for which currently available forms of therapy achieve unsatisfactory outcomes. Here, ABCB5 is linked to neurodegenerative disease.