In addition to their effects on the adaptive immune system, ABCB5+ MSCs suppress, in inflamed tissues, IL-1β and its downstream effector TNF-α [11], two inflammasome components that are critical to GvHD development [193,194], while enhancing IL-10 [11], which is vital for GvHD limitation [195]. The gene discussed is ABCB5; the disease is graft versus host disease.