TIMP1 and Hepatic fibrosis: Moreover, ABCB5+ MSCs did not induce toxicity regarding liver fibrosis (as assessed by collagen deposition and expression of Timp1, the gene encoding tissue inhibitor of metalloproteinases 1), inflammation (as assessed by expression of the pro-inflammatory cytokines Il1B and Il6 in liver tissue) or hepatocellular destruction (as assessed by expression of caspases 3 and 9 in liver tissue) as compared with vehicle-treated animals at week 7 after MSC application [103].