Finally, given that the pathogenesis of perpetuating organ and skin injury in GvHD has been attributed to endothelial vulnerability and damage associated with a strong decrease in VEGF levels during escalation of therapeutic immunosuppression [197,198,199,200,201], ABCB5+ MSCs might also attenuate GvHD via their strong pro-angiogenic potential [68,114]. This evidence concerns the gene VEGFA and graft versus host disease.