In this regard, intravenous administration of human ABCB5+ MSCs in a Col7a1−/− NSG neonatal RDEB mouse model reduced RDEB pathology and markedly prolonged the animals’ lifespans via significant reduction in skin infiltration of pro-inflammatory M1 macrophages [102]. The gene discussed is COL7A1; the disease is recessive dystrophic epidermolysis bullosa.