In an iron-overload mouse wound model mimicking the chronic inflammatory state of nonhealing human venous ulcers, which is characterized by persistent, unrestrained M1 macrophage activation [94], ABCB5+ MSCs injected intradermally around the wound edges of full-thickness excisional wounds localized within the wound bed in close association to endogenous murine macrophages [11]. This evidence concerns the gene ABCB5 and varicose ulcer.