In contrast, in conditions associated with sustained excessive macrophage infiltration into the skin, such as in the Col7a1−/− NSG neonatal mouse model of recessive epidermolysis bullosa (RDEB), intravenous application of ABCB5+ MSCs can strongly decrease CD68+ macrophage skin infiltration, leading to significant amelioration of disease activity [102]. Here, COL7A1 is linked to recessive dystrophic epidermolysis bullosa.