The potential of ABCB5+ MSCs to inhibit alloantigen-dependent T-cell proliferation and induce of Treg expansion could also be advantageous in the prevention and management of GvHD, a serious adverse reaction of allogeneic hematopoietic stem cell transplantation, which results from a systemic cytotoxic attack by alloantigen-specific donor T-cells on host tissues [192]. This evidence concerns the gene ABCB5 and graft versus host disease.