ABCB5 and autosomal dominant polycystic kidney disease: In the PKD/Mhm (Cy/+) rat model of the most common PKD type, i.e., autosomal dominant PKD (ADPKD) [131], systemic infusions of ABCB5+ MSCs elicited in the kidney cells a reversion of metabolic reprogramming from ADPKD-typical upregulation of alternative pathways of energy production such as glycolysis to oxidative phosphorylation, citrate cycle, gluconeogenesis, and pyruvate metabolism pathways [132].