The hepatic transcriptome of AIP mice revealed that phenobarbital also induced dysregulation of the gene involved in mitochondrial biogenesis (PGC1α) and oxidative phosphorylation, whose regulation closely depends on peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A, encoding the PGC1-transcription factor) [28]. This evidence concerns the gene PPARGC1A and autoimmune pancreatitis.